Care Begins  With Discovery: Explore Alzheimer’s Clinical Trials.

If you or a loved one has been diagnosed with Alzheimer’s disease (AD), you may feel overwhelmed — but you’re not alone. Alzheimer’s is the most common cause of dementia, accounting for an estimated 60% to 80% of cases, and though there is no cure yet, research continues every day. By participating in a clinical trial, you or your loved one help advance science that may benefit future generations.¹

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How Clinical
Trials Work

Thank you for your interest in learning more about Alzheimer’s disease clinical trials! Every day, academic institutions, pharmaceutical organizations and private research facilities across the country are diligently researching potential treatments through clinical trials in AD.

Here’s a look at what a clinical trial for Alzheimer’s disease might involve:

A principal investigator, or PI, is the physician in charge of the clinical trial, who is responsible for coordinating, managing and overseeing the clinical study. That individual carries out what is called a protocol.

Protocol is a document that describes how the trial is designed, and outlines how it should be carried out.

Clinical trials, also called research studies or clinical studies, can be either interventional, or non-interventional. Interventional studies mean that they test out an intervention, like an investigational drug, procedure or medical device. Non-interventional studies, also called observational studies, don’t test potential treatments. Instead, researchers observe the participants over a period of time, and track health outcomes.

WHO CAN PARTICIPATE?

Below are some primary criteria that interested individuals need to meet to participate in a clinical research study for Alzheimer’s disease:

Are at least 55 years of age, and no older than 90
Have a doctor-confirmed diagnosis of Alzheimer’s disease via PET scan, bloodwork, or MRI of the brain
Exhibit signs of memory loss, confusion, agitation, restlessness, hallucinations or delusions
Have a person in your/your loved one’s life with whom you/they spend 10 or more hours per week with on a regular basis who is willing and able to attend study visits, oversee medications, and help provide assessments (such as a spouse, caregiver, or an adult child)

Learn if you or a loved one may be eligible for participation in an Alzheimer’s disease clinical trial by clicking the link below.

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Understanding Alzheimer’s Disease (AD)

Alzheimer’s disease is a progressive brain disorder that slowly erodes memory, thinking skills, and eventually the ability to carry out everyday tasks. The disease begins when abnormal proteins build up in the brain, forming plaques and tangles that interfere with communication between brain cells and eventually cause those cells to die. Alzheimer’s disease typically develops in stages.² In the early (mild) stage, people may notice memory lapses or trouble finding words but generally are still able to live independently. In the middle (moderate) stage, symptoms worsen and can include confusion, personality changes, agitation, and difficulty with daily activities. In the advanced (severe) stage, individuals may lose the ability to speak, recognize loved ones, or care for themselves, requiring around-the-clock support.³

Mild to Moderate Alzheimer’s Disease

Mild to moderate Alzheimer’s disease is when symptoms like memory loss, confusion, and trouble with thinking or organizing tasks become more noticeable. People may repeat questions, lose track of time, or struggle with daily routines like paying bills or cooking. Mood changes such as anxiety, frustration, or withdrawal are also common. While individuals can often still live independently during the mild stage, more support is usually needed as the disease progresses. This is a key time to explore treatment options that may help slow symptoms or potentially improve quality of life.⁴ Are you or your loved one experiencing these symptoms?

Agitation in Alzheimer’s Disease

Alzheimer’s with agitation includes symptoms like restlessness, irritability, pacing, yelling, or sudden outbursts that can be triggered by confusion or changes in routine. These behaviors often appear in the middle or later stages of the disease and can be very stressful for both the person with Alzheimer’s and their caregivers. Agitation can come and go, and it may worsen in the late afternoon or evening. Finding ways to manage these symptoms is an important part of care, and clinical trials are working to develop treatments that can help reduce agitation safely.⁵ Are you or your loved one experiencing these symptoms?

Psychosis in Alzheimer’s Disease

Alzheimer’s disease with psychosis involves symptoms like hallucinations (seeing or hearing things that aren’t there) and delusions (false beliefs, such as thinking someone is stealing from them). These symptoms typically appear in the middle to later stages of the disease and can be frightening or confusing for both the person affected, as well as their caregivers. Psychosis can lead to increased distress, fear, or mistrust, making daily care more challenging. Current treatment options are limited and often come with serious side effects. That’s why clinical trials are exploring safer, more effective ways to manage these symptoms.⁶ Are you or your loved one experiencing these symptoms?

7,000,000

Alzheimer’s disease (AD) affects approximately seven million Americans. The brain changes that cause AD are thought to begin 20 years or more before symptoms start.⁷

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FREQUENTLY ASKED QUESTIONS

What are the benefits of participating in an Alzheimer’s disease clinical trial?

The information gathered from clinical studies may help identify potential treatment options in the future for people living with AD. Study participants are often connected to specialists who understand their situation and can help answer questions from patients or their loved ones. Participants in research studies should also expect a professional clinical environment during the trial.

Who may be a good candidate to apply for an Alzheimer’s disease clinical trial?

You may consider applying for a study if you or a loved one:

Are at least 55 years of age, and no older than 90
Have a doctor-confirmed diagnosis of Alzheimer’s disease via PET scan, bloodwork, or MRI of the brain
Exhibit signs of memory loss, confusion, agitation, restlessness, hallucinations or delusions
Have a person in your/your loved one’s life with whom you/they spend 10 or more hours per week with on a regular basis who is willing and able to attend study visits, oversee medications, and help provide assessments (such as a spouse, caregiver, or an adult child)

What will happen during a clinical trial for Alzheimer’s disease?

Most clinical trials will involve frontline screening to confirm that a potential patient is, in fact, a match for that study’s criteria. Once verified and the patient has signed an Informed Consent Form, which clearly provides the details and purpose of the study to that individual and what it involves, participants can expect to attend scheduled appointments at a participating clinical research site. They will also receive a study drug (also called an investigational medication) and undergo additional screening and follow-up monitoring.

Are there any costs to participate in a clinical research study?

There is no cost to participate in a clinical trial. Participants receive all study-related medical care and study medications for the duration of the study at no cost. Likewise in many instances, study participants may receive travel and meal reimbursement and compensation.

Are there any risks to participating in a clinical research study?

All investigational drugs and medical procedures come with a risk of side effects. Participants may potentially experience some discomfort or other reactions during or after a clinical trial. The study staff should explain these potential risks before participants decide whether to join the trial and help address any concerns they may have.

Can a person change their mind about participating in a clinical study?

Yes. Participation in clinical trials is entirely voluntary. Even if a study participant is already involved in a study, they may change their mind, leave, or remove consent at any time, for any reason.

What if I have more questions?

If you are interested in learning more, please contact us at any time. You may email us at help@clinicalenrollment.com.

Care Begins With Discovery: Explore Alzheimer’s Clinical Trials.

How Clinical Trials Work